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Rona K Graham Selected Research

Caspase 6

1/2018Activation of caspase-6 and cleavage of caspase-6 substrates is an early event in NMDA receptor-mediated excitotoxicity.
4/2016Interactome network analysis identifies multiple caspase-6 interactors involved in the pathogenesis of HD.
4/2015Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice.
5/2012Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice.
1/2012Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin.
1/2012Caspase-6-Resistant Mutant Huntingtin Does not Rescue the Toxic Effects of Caspase-Cleavable Mutant Huntingtin in vivo.
12/2011Caspase-6 and neurodegeneration.

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Rona K Graham Research Topics

Disease

22Huntington Disease (Huntington's Disease)
01/2018 - 09/2002
6Alzheimer Disease (Alzheimer's Disease)
01/2018 - 05/2004
5Neurodegenerative Diseases (Neurodegenerative Disease)
04/2015 - 01/2010
2Atrophy
11/2021 - 01/2012
2Body Weight (Weight, Body)
04/2015 - 04/2010
2Disease Progression
08/2013 - 01/2012
1Inflammation (Inflammations)
11/2021
1Wounds and Injuries (Trauma)
01/2018
1Nervous System Diseases (Neurological Disorders)
01/2018
1Stroke (Strokes)
01/2018
1Carcinogenesis
11/2016
1Brain Ischemia (Cerebral Ischemia)
04/2016
1Sudden Death
08/2015
1Cardiac Arrhythmias (Arrythmia)
08/2015
1Epilepsy (Aura)
08/2015
1Bipolar Disorder (Manic Depressive Psychosis)
12/2012
1Anhedonia
04/2009
1Mitochondrial Diseases (Mitochondrial Disease)
02/2006
1Sepsis (Septicemia)
05/2004

Drug/Important Bio-Agent (IBA)

10polyglutamineIBA
05/2015 - 09/2002
7CaspasesIBA
01/2018 - 09/2002
7Caspase 6IBA
01/2018 - 12/2011
6Proteins (Proteins, Gene)FDA Link
01/2018 - 09/2002
4N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA
01/2018 - 02/2006
2Insulin-Like Growth Factor I (IGF-1)IBA
04/2015 - 04/2010
2Huntingtin ProteinIBA
08/2013 - 08/2011
1Apolipoprotein E4IBA
11/2021
1N-Methylaspartate (NMDA)IBA
01/2018
1Messenger RNA (mRNA)IBA
01/2018
1Sodium Channels (Sodium Channel)IBA
08/2015
1SodiumIBA
08/2015
1Protein Isoforms (Isoforms)IBA
08/2015
1AcyltransferasesIBA
08/2014
1Neuroprotective AgentsIBA
12/2012
1Pharmaceutical PreparationsIBA
12/2012
1LithiumIBA
12/2012
1Peptides (Polypeptides)IBA
01/2012
1A-factor (Streptomyces)IBA
01/2012
1Caspase 2IBA
08/2011
1Insulin (Novolin)FDA Link
04/2010
1Growth Hormone (Somatotropin)IBA
04/2010
1Insulin-Like PeptidesIBA
04/2010
1Sucrose (Saccharose)IBA
04/2009
1Biological FactorsIBA
04/2009
1CalpainIBA
11/2008
1Quinolinic AcidIBA
07/2006
13-hydroxykynurenineIBA
07/2006
1Free RadicalsIBA
07/2006
1NeurotoxinsIBA
07/2006
1CalciumIBA
02/2006
1Amyloid beta-PeptidesIBA
05/2004
1EndotoxinsIBA
05/2004
1CytokinesIBA
05/2004
1Caspase 12IBA
05/2004

Therapy/Procedure

2Therapeutics
08/2013 - 09/2008